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Published studies indicate that patients who are CYP2C19 poor metabolizers where can I order soma 200 mg Washington have a 4 times increase in exposure to carisoprodol, and concomitant exposure to 50% decrease compared with normal CYP2C19 metabolizers meprobamate. The prevalence of poor metabolizers in Caucasians and African Americans is about 35% and in Asians is approximately 1.520%. The long-term studies in animals have not been conducted to evaluate the carcinogenic potential of carisoprodol. Carisoprodol is not formally evaluated for genotoxicity.

In published studies, carisoprodol was mutagenic in the in vitro test of mouse lymphoma where can I order soma 200 mg Washington cells in the absence of metabolizing enzymes, but was not mutagenic in the presence of metabolizing enzymes.

Carisoprodol was clastogenic in the chromosomal aberration test in vitro with cells of Chinese hamster ovary, with or without the presence of metabolizing enzymes. Other types of genotoxicity tests yielded negative results. Carisoprodol was not mutagenic in reverse mutation assay of Ames strains of S. typhimurium, with or where can I order soma 200 mg Washington without metabolizing enzymes, and was not clastogenic in a cell in vivo where can I order soma 200 mg Washington mouse micronucleus circulating blood. Carisoprodol has where can I order soma 200 mg Washington not been formally evaluated the effects on fertility. Published reproductive studies of carisoprodol in mice found no alteration in fertility although an alteration in reproductive cycles characterized by a greater where can I order soma 200 mg Washington time spent in estrus was observed with a dose of carisoprodol 1200 mg / kg / day . In a toxicology study of 13 weeks do not determine the fertility of the mouse testis weight and sperm motility was reduced at a dose of 1200 mg / kg / day. In both studies, the where can I order soma 200 mg Washington NOEL was 750 mg / kg where can I order soma 200 mg Washington / day, equivalent to about 2.where can I order soma 200 mg Washington 6 times the equivalent human dose of 350 mg four times daily, based on a comparison of the where can I order soma 200 mg Washington body surface. The importance of these findings for human fertility is unknown.

The safety and efficacy of carisoprodol in relieving acute pain idiopathic mechanical lower back was assessed on a 7-day double-blind, randomized, multicenter, placebo-controlled American (Study 1). Patients had to be between 18 and 65 and have where can I order soma 200 mg Washington severe back pain (3 days) to be included in the test.

Patients with chronic back pain, an increased risk of vertebral fracture (eg, history of osteoporosis), history of spinal pathology (eg, herniated disc, spinal stenosis or spondylolisthesis) with back pain show where can I order soma 200 mg Washington inflammation, or neurological deficits were excluded from participation. Concomitant use of analgesics (paracetamol, for example, NSAIDs, tramadol agonists, opioids), other muscle relaxants, botulinum toxin, sedatives (eg barbiturates, benzodiazepines, promethazine hydrochloride) and anti-epileptic drugs was prohibited. In where can I order soma 200 mg Washington Study 1, patients were randomly assigned to one of two treatment groups (ie, carisoprodol 350 mg or placebo).

In the study, patients received study medication three times daily and at bedtime for seven days. The main where can I order soma 200 mg Washington objectives were the relief of back pain start printing and global change, suchas reported by patients during the where can I order soma 200 mg Washington study day 3. Both ends are rated on a 5-point scale ranging where can I order soma 200 mg Washington from 0 (worst result) to 4 (best) in the study. The proportion of patients using concomitant acetaminophen, NSAIDs, tramadol agonists, opioids, other muscle relaxants, and benzodiazepines was similar in both treatment groups. The results of evaluations of effectiveness in the acute study, back pain are presented in Table 3. square average of at least average, and b is the standard error of the mean. Treated patients experienced an improvement in terms of carisoprodol, measured by the Roland Disability Questionnaire Morris (RMDQ) counts 3 and 7. Mgcomprimé 350 white, round tablets engraved without music "WW 176" on one side and back, available in bottles of 120, 45 and 90. Storage: Store at 20-25C (68-77F) [see controlled room temperature USP].